Endothelial Genes

Abstract

Breast cancer growth and metastasis are dependent on angiogenesis. Multiple angiogenic peptides have been identified and sequenced. These include basic and acidic fibroblast growth factor (bFCF and aFGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), transforming growth factor-alpha and beta (TGF-alpha and TGF-beta), hepatocyte growth factor (HGF), tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), granulocyte colony stimulating factor (G-CSF), E-selectin, angiogenin, platelet-derived endothelial cell growth factor (PD-ECGF), placental growth factor and pleiotrophin. Furthermore, several endogenous angiogenic inhibitors have recently been identified. These include thrombospondin, TMP-1 (tissue inhibitor of metalloproteinase), angiostatin, endostatin, METH-I and METH-2. Recently, our laboratory has utilized a subtraction hybridization technique to identify two novel genes: endomucin and EG-1 (endothelial-derived gene-1).

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2004
Accession Number
ADA424202

Entities

People

  • Mai N. Brooks

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Blood
  • Breast Cancer
  • Cancer
  • Cells
  • Confocal Microscopy
  • Endothelial Cells
  • Epithelial Cells
  • Immune Serums
  • Institutional Review Board
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Peptide Growth Factors
  • Peptides
  • Proteins

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).