Targeted Ablation of CML Stem Cells
Abstract
The purpose of this grant project is to identify and characterize methods for ablation of CML stem cells. Numerous studies have shown that malignant stem cells lie at the heart of CML disease; therefore, specific targeting of these cells is essential for more durable remission and cure. Consequently, we are employing both mouse and human model systems to study the nature of CML stem cells and to identify effective drug combinations that will preferentially destroy malignant stem cells while sparing normal cells. Studies to date in our mouse model system indicate that PS-341 may be a drug that effectively targets primitive CML cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA424233
Entities
People
- Craig T. Jordan
Organizations
- University of Kentucky