Data Development Strategy for Evaluation of Occupational Health Hazards of New Chemicals of Interest to the Air Force

Abstract

New chemicals developed for the use by the Air Force must undergo evaluation to determine if these chemicals will be detrimental to the health of Air Force personnel. Chemical safety assessment is a costly and time consuming process. This report is a description of recommended procedures for toxicity testing of new chemicals. A strategy for the progressive and logical development of toxicology data that are needed for health hazard characterization, and ultimately for risk assessment is presented. The overall cost and time requirements of the proposed testing strategy are provided. The relationship between the amount of toxicity testing conducted and the level of confidence in the toxicity classification of new chemical is emphasized.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2000
Accession Number
ADA424408

Entities

People

  • Andrey I. Nikiforov
  • Darol Dodd
  • John M. Frazier

Tags

DTIC Thesaurus Topics

  • Air Force
  • Air Force Personnel
  • Body Weight
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Chromosomes
  • Genetics
  • Laboratory Animals
  • Medical Personnel
  • Mutagenicity Tests
  • Risk Analysis
  • Rodents
  • Test And Evaluation
  • Test Methods
  • Toxicity

Readers

  • Critical Infrastructure Protection in CBRN and WMD Threats.
  • Systems Analysis and Design