Regulation of Apoptosis in Breast Cancer by NF-KappaB and IAB Axis

Abstract

Defects in apoptosis contribute to the pathogenesis and progression of breast cancer. One of the modulators of apoptosis is NF-KappaB, a family of heterodimeric transcription factors containing a conserved REL homology domain. Apoptosis relevant targets of NF-KappaB include Bfl-1, bcl-X(sub L), FLIP, cIAP2, and others. We sought to identify novel regulators of NF-KappaB. We identified novel members of a family of PAAD/PYRIN domain-containing proteins, called PAs2 and NAC. These proteins modulate activity of the I-KappaB kinases (IKKs). Discovery of these novel NF-KappaB regulators provides new insights into mechanisms of apoptosis regulation and also may be of relevance to immune responses to breast cancers.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2003
Accession Number
ADA424561

Entities

Organizations

  • Sanford Burnham Prebys Medical Discovery Institute

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Health Services
  • Neoplasms
  • Organic Chemistry
  • Programmed Cell Death
  • Proteins
  • Transcription Factors

Readers

  • Breast cancer cell signaling and growth regulation.
  • Cellular and Molecular Pathways of Apoptosis.