The Role of the Y-Located TSPY Gene in Prostatic Oncogenesis
Abstract
The TSPY gene is the only functional gene within the critical region harboring the gonadoblastoma locus on the Y chromosome (GBY). Expression studies demonstrated that it is aberrantly expressed in prostate cancer. This project is designed to address the role of this putative oncogene on the Y chromosome in this male-specific cancer. The objectives are: 1) to identify the oncogenic or tumor promoting domain in TSPY, and 2) to correlate TSPY over-expression with prostatic oncogenesis in transgenic mice. We have analyzed the expression of TSPY in additional cases of gonadoblastoma and samples from a tissue recombination model of human prostate cancer. Our results provide a detailed morphologic evolution of the oncogenic process in gonadoblastoma and demonstrated that TSPY expression is closely associated with oncogenesis. Using a tet-off system we demonstrated that expression of the different variants of TSPY proteins are capable of transforming cells at higher efficiencies and proliferating at faster rates than those without TSPY expression. The present research provides significant insights into the probable mechanism of TSPY function in oncogenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2004
- Accession Number
- ADA424616
Entities
People
- Yun-fai C. Lau
Organizations
- Northern California Institute for Research and Education