The Role of CBP/p300 in Breast Cancer Development
Abstract
CBP and p300 are highly related mammalian transcriptional coactivators that regulate gene transcription through various activities (Goodman and Smolik, 2000). Both coactivators are known to enhance gene transcription by linking sequence-specific transcription factors to the RNA polymerase II holoenzyme (Kee et al., 1996; Nakajima et al., 1997). They also promote gene transcription by forcing chromatin into conformations that are more accessible to DNA binding transcription factors through the acetylation of histones (Ogryzko et al., 1996). Besides histones, CBP and p300 also acetylate specific transcription factors. For instance, acetylation of p53 by CBP has been shown to enhance the DNA binding ability of p53 (Gu et al., 1997; Liu et al., 1999; Sakaguchi et al., 1998), and acetylation of CREB has been shown to stimulate CREB-mediated gene expression (Lu et al., 2003).
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2003
- Accession Number
- ADA424640
Entities
People
- Jan M. Van Deursen
Organizations
- Mayo Clinic