Enhancement of Prostate Cancer Radiotherapy by Immunogenetherapy
Abstract
The goal of the proposed study is to develop a genetic immunotherapy strategy that can compliment and enhance current prostate cancer radiotherapy. The specific strategy that will be adopted in this proposal is to test the capacity of an adenovirus encoding immunostimulatory genes IL-12 and B7 to enhance the therapeutic effects of ionizing radiation in an experimental murine prostate tumor model TrampC. A substantial progress has been made towards this goal. We have now conducted experiments where we combined radiotherapy and genetic immunotherapy in the TrampC1 model. The results indicate synergistic effects in controlling subcutaneous tumor growth. In addition, we have also discovered that our immunogene therapy approach had a limited efficacy in controlling metastatic tumor growth. We explored the possibility that this limited success is due the in-efficiency of gene transfer by the viral vectors. Our results indicated that a novel, telomerase-targeted replicative gene therapy approach can significantly enhance the efficacy of the gene transduction into prostate cancer cells. We will explore this novel and exciting vector approach in the next year for our prostate cancer gene therapy approach.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2004
- Accession Number
- ADA424647
Entities
People
- Chuan-yuan Li
Organizations
- Duke University