Mechanism of Action of Substituted Indanones in Multidrug Resistant Breast Cancer
Abstract
Our laboratory has recently synthesized a series of novel substituted indanones that are selectively toxic to multidrug resistant cancer cells, including breast cancer cell lines. In this application we proposed to characterize the mechanism of action of indanocine and to assess the in vivo anti-tumor activity of indanocine. During the second year we: - published the second report on the biological activity of indanocine (Cancer Res 2001 Oct 1;61(19):7248.54) - analyzed the indanocine-resistant stable cell line - identified the potential indanocine-binding site on tubulin - continued the animal testing of indanocine - studies the pro-apoptotic mechanism of action in non-dividing tumor cells The results shown in this annual summary demonstrate that indanocine is a very promising new anti-cancer agent, with selective activity in slowly-dividing or quiescent tumor cells. The positive early animal models suggest that indanocine could be soon ready for clinical trials.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2001
- Accession Number
- ADA424668
Entities
People
- Lorenzo M. Leoni
Organizations
- University of California, San Diego