The Establishment of an Inflammatory Breast Cancer Registry and Biospecimen Repository
Abstract
The Inflammatory Breast Cancer Registry (IBCR) enrolled its first patient Sept. 10, 2002, after completing all necessary IRB and HIPAA pre-study requirements. As of Nov. 1, 2003, 120 patients have asked to be enrolled in the IBCR and 110 have completed their interviews. Tissue blocks have been obtained from 51 patients and frozen surgical specimens have been collected from 10. A Biospecimen Advisory Board was established and procedures are now in place to send biospecimens to requesting laboratories on a pilot basis and determine the number of subsequent specimens sent based on the initial results. Five laboratories are currently collaborating with multiple assays being performed by three of them. The lessons learned from the first 50 patients are being presented at the San Antonio Breast Cancer Conference in December 2003. The data include the observation that approximately one third of IBC patients are initially diagnosed as having mastitis and are treated with up to five months of antibiotics before the diagnosis of cancer is made. Less than 25% of patients have a discrete mass identified on initial mammography. Most patients received standard IBC therapy (chemotherapy followed by mastectomy, additional chemotherapy and radiation) but some were not offered surgery.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA424681
Entities
People
- Paul H. Levine
Organizations
- George Washington University