The Role of Focal Adhesion Kinase and CAS in Integrin-Medicated Signaling on Distinct Forms of Laminin-5

Abstract

This report details final work on this project that was performed under a revised statement of work at BioForce Nanosciences, Inc. Ames IOWA. The goals of this project were to test the feasibility of creating ultraminiaturized protein arrays using the BioForce Nanoarrayer instrumentation for the long term goal of providing a platform for screening biomarkers during progression in human breast cancer cell lines. The results of this study prove feasibility of this method and provide the groundwork for an assay format that will be useful for conducting biomarker profiling studies from exceedingly small tissue biopsy samples, such as those obtained from laser capture microdissection.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2003
Accession Number
ADA424826

Entities

People

  • Janice L. Huff

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Adhesion
  • Alcohols
  • Biological Factors
  • Breast Cancer
  • Cell Line
  • Cell Membrane Structures
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Detection
  • Electron Microscopy
  • Protein Microarrays
  • Proteins
  • Proteomics
  • Self Assembled Monolayers

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology and Biomarker-Based Cancer Detection.
  • Technical Research and Report Writing.

Technology Areas

  • Directed Energy