Direct Detection of Microbial Infection Through Activation Coupling of the Toll-Like Receptors

Abstract

We have utilized germline mutagenesis to dissect innate immune sensing and effector pathways, and have made a number of important findings related to the mechanism of TLR signal transduction. In particular, we were able to solve the molecular basis of MyD88-independent signaling. and to determine the cause of adjuvanticity (signaling via Trif and the production of type I interferons). Finally, our work has led to the first realization of the importance of the TLR9 -> MyD88 signaling axis and the TLR3 -> Trif signaling axis in responses to MCMV. These discoveries have important implications for the further study of innate resistance to both viral and bacterial infections, for the development of vaccines, and for the design of molecular sensors of infection.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2004
Accession Number
ADA424869

Entities

People

  • Bruce Beutler

Organizations

  • Scripps Research

Tags

Communities of Interest

  • Sensors

DTIC Thesaurus Topics

  • Bacteria
  • Bacterial Infections
  • Couplings
  • Detection
  • Detectors
  • Early Warning Systems
  • Gram-Negative Bacteria
  • Infection
  • Listeria Monocytogenes
  • Molecules
  • Mutations
  • Proteins
  • Warning Systems
  • Wound Infections

Readers

  • Immunology
  • Oncology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech