Water Powered Bioassay System
Abstract
This project addresses critical technologies, including the acquisition, metering, buffering, delivery and assay for the processing of bio-fluids that enable the complete integration of microfluidic chips into systems. An all-plastic micromachined water-powered pump was first developed that provided a constant rate fluidic delivery of 0.2 1/hr without requiring electrical power. A low-leakage, hole-in-the-wall micro valve was demonstrated that provided fluidic resistance 255 times higher in the closed state than in the open state. A micro-accumulator was designed, fabricated, and demonstrated that repeatedly stored and delivered fluidic pressure and, with a combination of pumps and valves, formed the basic micro fluidic processing unit. The addition of integrated micro dialysis needles and a bioassay system completed the system by providing the capability of extracting interstitial liquid directly from tissue and making a real- time diagnosis. A water-activated micro power battery was constructed and operated that delivered 0.6 V of power, and was demonstrated by driving a 10 kohm resistor for more than one hour. These micro-fluidic components and system integration technologies are leading the way in developing a microsystem to process microfluidics on a single chip.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2004
- Accession Number
- ADA424947
Entities
People
- Liwei Lin
Organizations
- University of California, Berkeley