A Preliminary Study of Exposure to Pyridostigmine Bromide, Diethyltoluamide, JP-4 Jet Fuel and Stress on Male Sprague-Dawley Rats
Abstract
This study investigated effects on male Sprague-Dawley rats of exposure to combinations of simulated stress and low doses of pyridostigmine bromide, diethyltoluamide, and JP-4 jet fuel vapor. Blood and tissue samples were analyzed for gross pathology, histopathology, and clinical chemistry effects. Serum and brain regions were analyzed for neurotransmitter levels. Body weights, gross pathology, histopathology, and clinical chemistry results revealed no significant differences between groups. Significant increases in serum 5-hydroxyindoleacetic acid and 5-hydroxytryptamine levels were present in the treated animals as compared to controls. Two-dimensional gel electrophoresis analysis of liver, kidney, and plasma samples from animals exposed to a combination of all chemicals and stress showed a statistically significant alteration in protein expression compared to controls. Further research is needed to assess the effect of the individual chemicals studied in combination here.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1998
- Accession Number
- ADA425061
Entities
People
- H. F. Leahy
- J. S. Eggers
- K. L. Macmahon
- L. Narayanan
- R. E. Wolfe