The Calcium Channel CaT1 in Prostate Cancer Progression
Abstract
This project focuses on the potential role of the calcium-selective ion channel, CaTl, in prostate cancer progression. Although the physiological role of CaTl is still poorly understood, it may be a "store-operated" calcium pore, a type of channel that is known to play a role in cell growth and survival regulation. The Aims of this project are to (1) Develop specific antibodies against CaTl and characterize its expression pattern(s) in human prostate cancer tissues; and to (2) Determine the role of CaTl in cell growth and survival regulation in human prostate cancer cells. We have successfully completed most of the objectives in Aim (Task) 1. During the first funding year, we developed and characterized a CaTl antibody suitable for highly specific detection of the CaTl protein in tissues. We used this novel reagent to characterize the expression patterns of CaTl protein in mouse and human; we discovered that CaTl is expressed by a number of exocrine organs; and we discovered that CaTl is overexpressed in prostate, breast, thyroid, colon and ovarian carcinomas. These findings indicate that CaTl is likely to serve as a component of transcellular calcium transport mechanisms in many tissues and epithelial cancers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2004
- Accession Number
- ADA425066
Entities
People
- Michael R Freeman