Role of ART-27, a Novel Androgen Receptor Coactivator, in Normal Prostate and Prostate Cancer
Abstract
The Androgen receptor (AR) is a hormone-dependent transcription factor involved in the regulation of both normal and malignant prostate cell growth. However, the precise mechanisms by which AR regulates normal prostate development and initiates prostate cancer have yet to be elucidated. It is believed that co-factors (coactivators and corepressors) that interact with the AR and modulate its activity play an important role in these processes. ART-27, as a newly identified AR coactivator, its function in normal prostate development and prostate cancer need yet to be elucidated. Modulation ART-27 levels in vivo such as knocking out ART-27 in the mouse will be our ultimate answer to these questions. Meanwhile recent studies have suggested that ART-27 may confer AR-dependent growth suppression and differentiation, if so, any alteration in ART27:AR interaction with those N-terminal mutated AR identified in some prostate cancer patients, will provide important genetic evidence for the role of ART27 in human disease, such as prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2004
- Accession Number
- ADA425152
Entities
People
- Wenhui Li
Organizations
- NYU Langone Health