Investigating the Mechanisms of Action and the Identification of Breast Carcinogens by Computational Analysis of Female Rodent Carcinogens
Abstract
This project is investigating the potential that environmental estrogens may be involved in the etiology of breast cancer. We hypothesize that specific features of chemicals can be identified that are significantly associated with female and breast carcinogens and that these features are related to mechanisms of chemical carcinogenesis. Our overall scientific objective is to investigate the hypothesized relationship between environmental chemicals, xenoestrogens, and the development of breast cancer. As described we moved from Pitt to LSU, causing a lag in progress during renegotiations. We are on schedule and budget and have accomplished the bulk of work for Specific Aim 1 (or year one) . This includes MCASE SAR models for mouse, rat, female- specific, and mammary carcinogens. Due to multiple factors we are migrating our work from MCASE to Tripos Sybyl. Initial verification that Sybyl will perform the required tasks has been demonstrated. We anticipate about two manuscripts will shortly be produced from Specific Aim 1, describing our female and mammary carcinogen model and the utility of Tripos Sybyl software to adequately deal with environmental toxicants.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA425200
Entities
People
- Albert R. Cunningham
Organizations
- Louisiana State University