Functional Characterization of the Murine Homologue of PLAB a Novel TGF-B Member in Placental and Mammary Tissues
Abstract
Primate and mouse display marked morphological differences upon their entrance to gastrulation. The most overt of these are topological dissimilarities of the gross embryos. While primate embryos develop as a planar epiblast within a spheroidal cytotrophoblastic shell, mouse epiblast develops in a cup shape, surrounded principally by a cylindrical endoderm shell. At this stage, the bulk of the murine trophoblast is limited to the mesometrial pole of the cylinder, rather than encapsulated by the cytotrophoblast as in the primate embryo. Additionally, the appearance of the primate mesoderm is precocious with respect to that of the mouse. Primate extraembryonic mesoderm is evident in sectioned tissues prior to the established of a primitive streak or node. In the mouse, such mesoderm appears only after establishment of these structures. We are developing a new model of non-human primate biology using interspecific chimeras produced within tetraploid mouse blastocysts. By using tetraploid blastocysts in...
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2003
- Accession Number
- ADA425574
Entities
People
- Guy S. Eakin
Organizations
- The University of Texas MD Anderson Cancer Center