Endothelial Cell-Targeted Adenoviral Vector for Suppressing Breast Malignancies
Abstract
The survival, growth and metastasis of solid tumors including breast cancer depends on the formation of new blood vessels to provide tumors with nutrients and oxygen, a process called angiogenesis. In vitro and in vivo experimental models indicate that suppressing angiogenesis can also suppress solid tumors. However, the success of this approach largely depends on whether sufficient amounts of therapeutic agents can be delivered to tumor-associated endothelial cells without causing toxic effects to other tissues/cells. Our proposal is designed to develop an endothelial cell-targeted adenoviral vector and to use the targeted vector to express high levels of anticancer therapeutic genes in the sites of angiogenenic tumors specifically and efficiently.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2004
- Accession Number
- ADA425596
Entities
People
- Shuang Huang
Organizations
- Scripps Research