A Novel Approach to Monitoring Prostate Tumor Oxygenation: Proton MRI of the Reporter Molecule Hexamethyldisiloxane
Abstract
Crowing evidence from experimental and clinical studies confirms that solid human tumors have foci of hypoxic cells, which have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy. A strong argument therefore exists for assessing the hypoxic fraction of tumors prior to patient treatment, and to tailor this treatment accordingly. It has been shown that there is linear relationship between R of hexamethyldisiloxane (HMDSO) and p02, and the Rl of HMDSO is insensitive to various ions and minimally sensitive to temperature. The primary sequence for in vivo Tl measurement with water suppression has been established, and HMDSO is also detectable in prostate tumor. So, Hexamethyldisiloxane shows promise as a reporter molecule to measure tumor oxygenation by 1H MRS and potentially by MRI. This opens new opportunities for MR tumor oximetry, particularly since HMDSO is used widely in biomedical materials and as an ingredient in consumer products; and HMDSO is reported to have minimal toxicity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2004
- Accession Number
- ADA425618
Entities
People
- Weina Cui
Organizations
- University of Texas at Dallas