Polyphenols and Prostate Cancer Chemoprevention
Abstract
The polyphenols, catechin, (-)-epigallocatechin-3-gallate (EGCG), genistein and resveratrol, are associated with reduced incidences of prostate and breast cancers. The goal of this research is to investigate the potential of these 3 pure polyphenols, alone and in combination, to protect against prostate cancer in an animal model that spontaneously develops prostate cancer (TRAnsgenic Mouse Prostate adenocarcinoma (TRAMP)). In this manner, it may be possible to ingest moderate amount of each of these foods/chemicals, as opposed to mega amounts of one, and receive an additive or synergistic protective effect without adverse effects with possible elevated exposure. The specific aims are 1) to investigate the potential of genistein, EGCG and resveratrol, alone and in combination, to suppress the development of spontaneously developing prostate tumors and 2) to investigate the potential of genistein, EGCG and resveratrol to regulate sex steroid- and specific growth factor-receptor and ligand expression as mechanism of prostate cancer prevention. To date, the offspring were evaluated for transgene expression, and male TRAMP mice were subjected to these nutritional chemicals in AIN-76A diet or to control diet (AIN-76A), starting at 5 weeks postpartum. Each group contains 30 TRAMP males. Necropsy is scheduled for April - June 2004. Aim 2 has been initiated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2004
- Accession Number
- ADA425650
Entities
People
- Coral A. Lamartiniere
Organizations
- University of Alabama