Biochemical Markers of Brain Injury: An Integrated Proteomics Based Approach
Abstract
In addition to being the leading cause of death for civilians under 45 years of age, recent studies have confirmed that traumatic brain injury (TBI) is one of the most frequent causes of morbidity and mortality on the modern battlefield. Specifically, 40% of battlefield fatalities in the Viet Nam war were due to head wounds. It has been reported that of patients arriving alive at military field hospitals, 20% with extremely severe brain wounds die before surgery was performed, and 80% received neurosurgical treatment, with a 10% surgical mortality rate. Penetrating head injury alone accounts for 25% of all wartime casualties and approximately 40% of these injuries are fatal. Recently, studies of casualties during the Iraqi Conflict suggest that as many as 2/3 of combat casualties have associated concussive brain injuries. Thus, the current proposal focuses on development of non-invasive diagnostics of TBI that ultimately will be useful in a battlefield environment. The research has been divided into 3 SOWs. The SOWs are as follows: SOW 1: To employ integrated proteomics-based technologies to identify specific proteins or peptide fragments in brain released into CSF and/or blood of rats following experimental traumatic brain injury (TBI) or focal cerebral ischemia (middle cerebral artery occlusion: MCAO).
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2004
- Accession Number
- ADA425658
Entities
People
- Ronald L. Hayes
Organizations
- University of Florida