TRAIL-Based Radio-Gene Therapy for Prostate Cancer

Abstract

A recombinant gene was constructed, encoding the soluble form of the human Flt3L gene (hFlex) at the 5' end and the human TRAIL gene at the 3' end. This plasmid (phFlex/TRAIL) was administrated by the hydrodynamic-based gene delivery. As a result, tumor growth was significantly delayed by hFlex/TRAIL plasmid administration. For the expression of GOD, hybrid yeast promoter-containing vector was constructed, confirming the GOD expression. In vivo studies were conducted to examine the effects of intratumoral GOD-IT administration on nude mice. As a result, tumor growth was delayed by GOD-IT administration.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2004
Accession Number
ADA425662

Entities

People

  • Jae J. Song

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Coding
  • Diseases And Disorders
  • Gene Delivery
  • Gene Therapy
  • Hydrogen
  • Neoplasms
  • Peroxides
  • Prostate
  • Prostate Cancer
  • Proteins
  • Rocket Oxidizers
  • Therapy

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular Biology and Genetics
  • Political Violence and Terrorism Studies.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech