Regulation of Cell Cycle by BCCIP a BRCA2 and CDKN1(p21) Interacting Protein

Abstract

DAMD17-03-1-0317 is an IDEA award that focuses on the roles of BCCIP in cell cycle regulation. The approaches are over-expression and down-regulation of BCCIP by RNAi. The project has been moving on smoothly in the first 12 months. We have accomplished the scientific objectives of tasks 1-3, and 50% of tasks 4-5. We have published one paper based on this study. As an un-anticipated discovery, we have found that BCCIP also regulates p2l expression. This finding further strengthens our central hypothesis that BCCIP regulates cell cycle control. In the next funding year, we will strive to accomplish the objectives of tasks 5-6.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2004
Accession Number
ADA425667

Entities

People

  • Zhiyuan Shen

Organizations

  • University of New Mexico

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acids
  • Amino Acids
  • Anti-Bacterial Agents
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Gene Therapy
  • Genetics
  • Infection
  • Microbiology
  • New Mexico
  • Proteins
  • Regulations
  • Tissue Extracts
  • Tumor Cell Line

Readers

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