Effects of CSK Homologous Kinase Overexpression on HER2/Neu-Mediated Signal Transduction Pathways in Breast Cancer Cells

Abstract

Our proposal aims to investigate in details the potential function of CHK in breast cancer as a signal transducer in the signaling pathway from HER2/Neu receptor. The studies conducted in the period reported included: 1) studies on the effects of CHK on the HER2/Neu-induced tumorigenesis in vivo, and 2) generation of CHK-derivatives. Our major findings are as follows: Task 2: We created transgenic mice to study the effects of CHK on ErbB2-mediated signaling in vivo as well as on ErbB2-induced mammary tumor formation in vivo. Task 3: We used an alternative approach to successfully generate CHK derivatives which can be used in experimental CHK-based protein therapy of mammary tumors.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2004
Accession Number
ADA425671

Entities

People

  • Hava Avraham
  • Radoslaw Zagozdzon

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Acids
  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Cultured Cells
  • Demographic Cohorts
  • Enzymes
  • Eukaryotes
  • Genetically Modified Organisms
  • Mammary Glands
  • Neoplasms
  • Tissues
  • Tumor Cell Line

Readers

  • Breast cancer cell signaling and growth regulation.