SDF-1 DC1/DC2 and Tumor Angiogenesis

Abstract

Ovarian carcinomas have a poor prognosis, often associated with multifocal intraperitoneal dissemination accompanied by intense neovascularization. To examine tumor angiogenesis in the tumor microenvironment, we studied malignant ascites of patients with untreated ovarian carcinoma. We observed high numbers of plasmacytoid dendritic cells (PDC) and significant stromal derived factor (cxcL-12/sDF)-l in their malignant ascites attracting PDC into the tumor environment. We now show that tumor associated PDC induced angiogenesis in vivo. By contrast, myeloid dendritic cells (MDC) were absent from malignant ascites. MDC derived in vitro suppressed angiogenesis in vivo. Thus, the tumor may attract PDC to augment angiogenesis, while excluding MDC to prevent angiogenesis inhibition. Although dendritic cells have long been known to affect tumor immunity, these data also implicate them in tumor neoangiogenesis.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2004
Accession Number
ADA425742

Entities

People

  • Weiping Zou

Organizations

  • Tulane University of Louisiana

Tags

DTIC Thesaurus Topics

  • B Lymphocytes
  • Blood
  • Breast Cancer
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Techniques
  • Epithelial Cells
  • Hepatitis
  • Hiv Infections
  • Immunity
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Neoplasms
  • Peptide Growth Factors

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biology
  • Oncology (Cancer Research).