Stem Cells in Prostate

Abstract

This project aims to identify adult prostate stem cells, using tissue recombination techniques. To date, we have initiated studies utilizing mouse and human embryonic stem (ES) cells as outlined in the original statement of work. We have made progress towards directing differentiation of these ES cells into prostate lineages. We have shown pathologically and histologically that the resultant tissue recombinants have several characteristics of mouse and human prostate. Specifically, we have demonstrated tissue differentiated from human ES cells that have all the hallmarks of human fetal prostate. We are currently refining the technique in the hope of getting tissues that are immuno-positive for the unequivocal marker of mature prostate, within Australia and further findings will be presented in the coming months at several international meetings.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2004
Accession Number
ADA425754

Entities

People

  • Gail Petuna Risbridger

Organizations

  • Monash University

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Australia
  • Biomedical Research
  • Cancer
  • Cells
  • Embryos
  • Epithelial Cells
  • Epithelium
  • Molecular Weight
  • Prostate
  • Prostate Cancer
  • Stem Cells
  • Tissues

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Systems Analysis and Design

Technology Areas

  • Biotechnology