EGF Regulation of Nuclear Co-Activator AIB1 Function in Breast Cancer

Abstract

Various growth factor receptor pathways promote human breast tumorigenesis of hormone independent tumors. The nuclear receptor coactivator AIBl (amplified in breast cancer 1) can be phosphorylated and regulated by growth factor-induced signaling pathways such as MAP kinase and IkB kinase. Our lab has found a splice variant of AIBl, called delta exon3 AIBl, which has a higher co-activating ability than the full-length protein. This study determined the ability of delta exon3 splice variant compared with AIBl in potentiating growth factor signaling and to determine the mechanism of this potentiation using a growth factor responsive promoter.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2004
Accession Number
ADA425761

Entities

People

  • Anna Riegel
  • Annabell Oh

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Estrogens
  • Genes
  • Growth Factors
  • Hormones
  • Kinases
  • Mammary Glands
  • Neoplasms
  • Regulations
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.