Preclinical Mouse Models of Neurofibromatosis
Abstract
This report describes the third year of research effort by a Consortium of investigators who are working to develop, characterize and utilize strains of mice that accurately model tumors that develop in persons with NFl and NF2. This Consortium has made substantial progress toward accomplishing the goal of generating models of NF1 and NF2-associated tumors for biologic and preclinical therapeutic trials and of exploiting these mice to address biologic and preclinical questions. The Consortium organized a successful conference on the pathologic classification of murine NF-associated neural tumors. Many of the novel strains that have been developed have been shared widely with the research community. The investigators have collaborated closely and have shared expertise and reagents extensively. This NF Consortium has been admitted to the Mouse Models of Human Cancer Consortium of the National Cancer Institute and is participating fully in the activities of the group. The current award will support these collaborative studies through 2OO5.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2003
- Accession Number
- ADA425805
Entities
People
- Andrea I McClatchey
- Kevin M. Shannon
- Luis F. Parada
- Marco Giovannini
- Tyler Jacks
Organizations
- University of California, San Francisco