Military-Relevant Infectious Diseases Endemic to Kenya: Epidemiology Immunology Pathophysiology Treatment and Prevention
Abstract
Growth in operations continued particularly in the field sites in Nyanza and the Rift Valley Provinces during the second year of the Cooperative Agreement. State-of-the-art clinical research facilities were opened in Kombewa (November 2003) and Kericho (March 2004) for malaria and HIV/AIDS intervention studies, respectively. Kericho now has a new maternal and child health clinic and construction is underway to extend the Kombewa clinical research facility. A pediatric wing and modem research laboratory buildings will be ready for occupancy during the final year of the agreement. A 135 children dose and age stratified Phase 1 clinical trial for MSP-1 and an epidemiological study involving 276 children is in progress at the Kombewa field site. Both studies are in their follow-up phase. In Kericho, a retrospective economic impact study was completed and published results demonstrate a significant decrease in earnings of both the infected worker and the employer. A prospective comparison of ElA and Western blot testing with four rapid tests in 486 subjects enrolled in an HIV-l sero-incidence study was undertaken in Kericho. The sensitivity of all four rapid tests was 100% and specificity ranged from 99.1% to 100% with high positive and negative predictive values. Recruitment into the cohort development protocol in preparation for future HIV/AlDS vaccine intervention studies also commenced this year. Over 2600 subjects have been enrolled with some groups already into their first six month follow-up visit. Work in leishmaniasis was initiated with the arrival of Ellison Fellows to the unit under a special new NRC program. A pathway for prostaglandin synthesis in the parasite has been described and published. A potential role for this novel pathway in the life cycle or pathogenesis of the parasite is under investigation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2004
- Accession Number
- ADA425808
Entities
People
- Davy K. Koech
Organizations
- Kenya Medical Research Institute