Sequence Variants in Estrogen Receptors and Risk for Prostate Cancer
Abstract
This post doctoral research training aims to prepare the trainee for further prostate cancer research through a genetic epidemiology study of the role of estrogen receptors (ERs) in prostate cancer etiology. Two goals were proposed in this postdoctoral training project: 1) to further the trainee's ability to be an efficient researcher of prostate cancer genetics by enhancing the trainee's ability to use bioinformatics tools for genetic data analyses. 2) to comprehensively evaluate multiple genetic variants in ER genes using both family-based and case-control study designs, thus providing the trainee with real- world experience in genetic and bioinformatics analyses. Consistent with those%%goals, major accomplishments in the first half of the training period include: 1) attending statistic and bioinformatics courses, conferences, and workshops. 2) complete sequencing of all 14 exons, and the -2kb promoter region of the ESR2 gene in 96 subjects for the identification of mutations and sequence variants. 3) application of the statistics and bioinformatics skills gained in various courses and workshops for several similar genetic epidemiological studies. The screening of sequence variants in ESR1, as well as the genotyping of both ESR1 and ESR2, are both ongoing. The analyses and results are expected during the rest of the training period.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2004
- Accession Number
- ADA425852
Entities
People
- Bao-li Chang
Organizations
- Wake Forest University