FGF Signaling and Dietary Factors in the Prostate
Abstract
Purpose: To study the FGF signaling axis in prostate homeostasis and tumorigenesis, to evaluate dietary factors in modulating FGF signals in the prostate. Scope: to develop mouse models resembling human prostate tumor progressions for screening therapeutic strategies for prostate cancers and evaluating dietary factors in prostate cancer prevention. Major Finding: Ectopic expression of the constitutively-active GFGR1 (caGFGR1) in the prostate induces high-grade prostatic intraepithelial neoplasia (PIN) in transgenic mice. The development of PIN and degree of homeostasis perturbation in the prostate are caFGFR1 expression level-dependent. Repression of the resident FGFR2 in the prostate poentiated the lesions induced by the ectopic caGFGR1. Up-to-date Progress: The major findings are published in Cancer Research. We have established mouse colonies with prostate-specific disruption of Fgfr2 loci and expression of the ectopic caFGFR1 for further characterizations of the FCF signaling and dietary factors in prostate lesions. Significance: Together with previous data form the Dunning prostate tumor model, the findings demonstrate that aberrant FGF signals in the prostate strongly disrupt tissue homeostasis, and promote prostate tumor development and progression. - The model provides a useful tool for evaluating other tumor initiating factors, including those that cause genetic instability and other oncoqenic lesions in prostrate tumorigenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2004
- Accession Number
- ADA425856
Entities
People
- Fen Wang
Organizations
- Texas A&M University