A Chemopreventive Trial to Study the Effects of High Tea Consumption on Smoking-Related Oxidative Stress
Abstract
Our overall goal is to develop a sage and feasible model for the chemopreventive of a wide range of tobacco-related diseases. Our immediate goal, that is addressed over a 4-year study period, is to determine the effects of high tea consumption on biological markers of -oxidative stress that mediate lung cancer risk. We are conducting a 6-month randomized, controlled, double-blinded chemopreventive trial in a group of COPD subjects who are being randomized to green or black tea preparations or a control intervention (matching placebo). Levels of 8-hydroxydeoxyguanosine and 8-F2-isoprostanes will be use dot measure DNA and lipid damage respectively. Changes in biomarkers of oxidative damage will be measured in urine, blood, and exhaled breath condensate. The study protocol was approved by all parties in September 2003. Recruitment and screening of participants for eligibility criteria-a started in October 2003. By the end of December, 28 participants signed the consent form and were screened for eligibility criteria (spirometry for lung function). Eight subjects with FEV1>85% of. the standard were excluded for the study and 3 subjects dropped out. Currently 17 eligible subjects were enrolled in the study. Eleven subjects are completing the 1-month run-in period and 8 subjects have been randomized. We expect that adherence to a regular pattern of tea is feasible and quantifiable among this high risk population.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2004
- Accession Number
- ADA425871
Entities
People
- Iman A. Hakim
Organizations
- University of Arizona