Evaluation of the Role of the Metastasis-Suppressor Gene MKK4/SEK1 in Transgenic Models of Prostate Cancer

Abstract

Metastasis-suppressor genes suppress the growth of metastases without affecting tumor growth. We have been studying the role of inactivation of one such metastasis suppressor gene, Map Kinase 4 (MKK4) in the process of metastatic colonization. Work proposed in this application is aimed at extending our ongoing studies in the AT6.1 model system into new transgenic models of prostate cancer. In the past year we have made significant progress in the immunohistochemical studies proposed in the initial application and the development of gene targeting vectors for animal studies.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2003
Accession Number
ADA425959

Entities

People

  • Carrie W. Rinker-schaeffer

Organizations

  • University of Chicago

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Antibodies
  • Biological Staining And Labeling
  • Biomedical Research
  • Cancer
  • Cells
  • Chemistry
  • Metastasis
  • Neoplasms
  • Organic Solvents
  • Prostate
  • Prostate Cancer
  • Stem Cells
  • Suppressors
  • Targeting
  • Test And Evaluation
  • Tissues

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).
  • Systems Analysis and Design