Permanent Implantation Brachytherapy for Prostate Cancer Using a Mixture of Radionuclides With Different Half Lives
Abstract
Overall objective of this project was to test whether the therapeutic effectiveness of permanent implant brachytherapy for prostate cancer can be improved by using a combination of short and long half life radionuclides simultaneously. A theoretical model for continuous low dose rate irradiation (CLDRI) using a mixture of radionuclides was developed. Experiments were performed using BA1112 tumor and Chinese Hamster cells in vitro and BA1112 cells in vivo as solid tumors in WAG/rij rats. Radiobiology parameters for these cells were determined and used in the theoretical radiobiology model to improve our understanding of the experimental observations. Afterloading applicators for in vivo irradiations as well as animal care procedures were developed. In vivo experiments for tumor growth studies using the BA1112 rat model with 125I, 103Pd and a 50:50 mixture of the two were performed. Irradiations at S cGy/hr did not result in any tumor cures. At 16 cGy/hr tumor cures were observed in 1251 alone, 103Pd alone and in the 50:50 mixture. A higher than expected tumor cure rate was observed in the CLDRI using a 50:50 mixture of 1251 and Pd seeds. More experiments are required to prove and quantify this observation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2004
- Accession Number
- ADA425984
Entities
People
- Ravinder Nath
Organizations
- Yale University