Understanding the Role of Replication Protein A and RAD52 in Breast Cancer

Abstract

This research focuses on structural studies of human replication protein A (RPA) and RAD52 in recombination-based repair of double-stranded DNA breaks. This DNA repair pathway has been directly linked to breast cancer through BRCAl and BRCA2 protein-protein interactions. Also, mutations in the ataxia telangiectasia (AT) gene are implicated in breast cancer and recently AT kinase was shown to phosphorylate the N-terminus of the 32 kDa subunit of RPA. The goals of the Borgstahl Laboratory are to understand the role of RPA phosphorylation and RPA/RAD52 protein-protein interactions in DNA repair. The ultimate goal of this research is to provide an understanding of this process at the atomic level.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2004
Accession Number
ADA425985

Entities

People

  • Gloria E. Borgstahl

Organizations

  • University of Nebraska Medical Center

Tags

Communities of Interest

  • Autonomy
  • Biomedical

DTIC Thesaurus Topics

  • Albumins
  • Amino Acids
  • Biomedical And Dental Materials
  • Biomedical Research
  • Breast Cancer
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Crystal Structure
  • Crystallography
  • Crystals
  • Ionizing Radiation
  • Medical Personnel
  • Neoplasms
  • Organic Chemistry
  • Piezoelectric Crystals
  • Surface Plasmon Resonance

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology