The Role of N-Cadherin in Breast Cancer Metastasis

Abstract

The intracellular signaling events that cause tumor cells to become metastatic are not well understood. N-cadherin and FGF-2 synergistically increase migration, invasion and secretion of extracellular proteases in breast tumor cells. Here, we define a metastatic signaling cascade activated by N-cadherin and FGF-2. In the presence of N-cadherin, FGF-2 MAPK-ERK pathway, leading to MMP-9 gene transcription and cellular invasion.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2004
Accession Number
ADA426050

Entities

People

  • Rachel Hazan

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Adhesives
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Growth Factors
  • Membranes
  • Metastasis
  • Molecules
  • Neoplasms
  • New York
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Biology

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