Drug Development and Conservation of Biodiversity in West and Central Africa
Abstract
This report concerns activities of Associated Project #3 (AP#3) of the International Cooperative Biodiversity Group Program (ICBC) directed by the Walter Reed Army Institute for Research (WRAIR). This project examines medicinal plants of Central and West Africa as anti-typanosomal and anti-trichomonal agents. In the reporting period 85 plant extracts were received from WRAIR and 34 were received from the University of Dschang (Cameroon, AP#2). Extracts were screened in vitro vs. blood stream forms of African trypanosomes (Trypanosoma brucei, Trypanosoma rhodesiense) and pathogenic trichomonads (Trichomonas vaginalis, Tritrichomonas foetus). In the trypanosome growth screen, 58 WRAIR extracts and 8 AP#2 extracts were tested. Eight WRAIR extracts were tested vs metronidazole-resistant and -sensitive strains of T. vaginalis and another 31 were studied in a T. foetus screen. Of 58 WRAIR extracts tested 24 had IC50 values <20 microg/ml in the trypanosome screen. For trichomonads 2 of 8 WRAIR extracts had MIC values <0.6mg/ml for metronidazole-resistant T. vaginalis; 4 of 31 extracts were similarly active for T. foetus. For trypanosomes, plant genera yielding active extracts included: Melian, Holarrhena, Jatropha and Boerrhavia. For trichomonads, active extracts were from: Aspilia, Combretum, Enantia, Hoslundia, Mormadica, Phyllanthus and Cleistophotis.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2003
- Accession Number
- ADA426057
Entities
People
- Cyrus J. Bacchi
Organizations
- Pace University