Evaluation of Response to Induction Therapy in Breast Cancer With Phosphorus-31 Magnetic Resonance Spectroscopy
Abstract
The objective of the proposed research is to develop 1H-decoupled 31P magnetic resonance spectroscopy (MRS) techniques for measuring non-invasively the response of breast cancer to induction or preoperative chemotherapy. We hypothesize that the quantitative assessment of the effectiveness of a treatment using 31P MRS will be clinically feasible at 3.OT. Although the hardware modifications made to the MR scanner to enable 31P MRS were completed, and a breast RF coil was constructed and tested successfully, significant delays in the delivery of the scanner and in the manufacturer providing scanner software to properly operate at the phosphorus frequency resulted in poor progress. Patient scanning was not achieved. It is expected that some patients will be scanned in the near future using another source of funding in order to complete the goals of the study.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2003
- Accession Number
- ADA426058
Entities
People
- Jerome L. Ackerman
Organizations
- Massachusetts General Hospital