Drug Development and Conservation of Biodiversity in West and Central Africa
Abstract
This is the final report of associated project (AP #3) of the International Cooperative Biodiversity Group (ICBG) Program, which was headed by the Walter Reed Army Institute for Research (WRAIR). The project involves screening extracts of medicinal plants from Central and West Africa for growth-inhibitory activity vs. human and veterinary pathogenic African trypanosomes and trichomonads. Both drug-sensitive and drug-refractory isolates of each group were used. During this period approximately 281 extracts were received from WRAIR and the University of Dschang, Cameroon (AP #2). Approximately 2600 individual as says were done for trypanosomes to obtain IC(sub 50) values or growth inhibition data for 253 extracts. An additional 47 extracts were screened vs. trichomonads, comprising ^300 assays, and minimal inhibitory concentration (MIC) values obtained for all with at least one isolate. Forty-two extracts had IC(SUB 50) values of < 1.0 microngram/ml for trypanosomes, and 38 had MIC values of < 0.6 mg/ml for one or more of the trichomonad isolates. Some of the plant genera providing highly active material vs. trypanosomes were: Premma, Cassia, Guarea, Melian, Goyania, Culcasis, Hyptis, Cassytha, Holarrhena , Jatropha, Combretum, Renealima, Boerrhavia and Etythrina. Among the most active extracts vs. trichomonads were those from: Aspilia, Combretum, Enantia, Hoslundia, Mormodica, Phyllanthus, Cleistopholis, Mitracarpus, and Draecaena.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA426078
Entities
People
- Cyrus J. Bacchi
Organizations
- Pace University