Sulfur Mustard Damage to Cornea: Preventive Studies

Abstract

Studies are in progress to determine the efficacy and mechanism of a formulation containing anti-alkylating, antioxidants and metabolic accelerators present in VM against mustard induced skin toxicity. A preventive effect has been observed at the level of tissue morphology. Studies are in progress at the level of cellular metabolism, Here, CEES has been used as a representative compound simulating the action of sulfur mustard (HD). It has been demonstrated for the first time that application of this formulation is effective even post exposure to mustard, Prophylaxis is not absolute. VM has been found to be useful even for inducing tissue regeneration adversely affected by the mustard compound

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2004
Accession Number
ADA426106

Entities

People

  • Shambhu D. Varma

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Alkylation
  • Biomedical Research
  • Cell Membrane
  • Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Epidermis
  • Epithelial Cells
  • Epithelium
  • Free Radicals
  • Membranes
  • Metabolism
  • Oxidative Stress
  • Rodents
  • Stress (Physiology)
  • Tissues

Readers

  • Geochemistry
  • Toxicology/Environmental Toxicology