Ultra Short Pulse Electroporative Physics and Technology
Abstract
The project has demonstrated that ultra-short, high-field pulses are a useful tool for study of cellular physiology, and a potential therapeutic instrument for malignant cells. The research has established that intracellular effects including apoptosis can be induced by the application of short, intense (but low total energy) electric pulses. Experiments on human cells have produced convincing evidence that these applied fields nondestructively alter subcellular processes and can be investigated using biophotonic studies for imaging of morphological and functional changes at subcellular levels. The results suggest a promising pathway toward achieving the ultimate goal of selectively disabling tumor or other undesirable cells. In addition to demonstrating that ultrashort pulses have potentially important applications for cell and cancer biology investigations, and for understanding the application of pulsed fields to living matter, these results demonstrate that an effective and productive multidisciplinary collaboration between science, engineering, medicine and biology has been created. nanosecond high-field electric pulse electrnpenturbaUon, electroporation, pulse-Induced phospholipid translocation, nanoelecfropuls%
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2004
- Accession Number
- ADA426112
Entities
People
- Martin A. Gundersen
Organizations
- University of Southern California