Extending the Refrigerated Storage of Red Blood Cells

Abstract

Oxygen removal increases shelf-life and quality of refrigerated blood. The shelf life of our blood has been prolonged to a minimum of 12 weeks with survival equal to or greater than that of conventional 6 week storage. Increased quality is evident in increased ATP and DPG. This may result from increased binding of ATP and DPG to hemoglobin as a consequence of oxygen removal. The extent of quality improvement and prolonged shelf life are not yet maximal. Strong possibilities exist for further enhancing quality and prolonging shelf life. A self-regulating blood bag compatible with conventional storage facilities has been designed and awaits testing.

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Document Details

Document Type
Technical Report
Publication Date
Sep 20, 2004
Accession Number
ADA426446

Entities

People

  • Mark W. Bitensky
  • Tatsuro Yoshida

Organizations

  • Boston University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Additives (Chemicals)
  • Biomedical Engineering
  • Blood
  • Blood Cells
  • Blood Preservation
  • Blood Storage
  • Blood Transfusions
  • Cell Membrane
  • Cells
  • Classification
  • Engineering
  • Information Operations
  • Membranes
  • Shelf Life
  • Storage
  • Survival

Readers

  • Cardiovascular Physiology
  • Systems Analysis and Design