There is no Difference in the Incidence of Postoperative Nausea and Vomiting (PONV) When Ondansetron (ZOFRAN) is Administered Prior to Induction or Emergence from General Anesthesia
Abstract
The purpose of this study was to determine if ondansetron is more effective in the prevention of PONV when administered prior to induction versus prior to emergence from general endotracheal anesthesia. This was a prospective, randomized, double-blind study of ASA I-Ill patients. Group I received ondansetron at induction (n = 75) and Group II received ondansetron at emergence (n = 75). A general anesthesia protocol was followed and data was collected in the recovery room and at 24 hours. Group I had a 28.1 % incidence of nausea in the PACU and 1.2 hours of nausea for the 24 hours post emergence, while Group II had a 23.4% incidence in the PACU and 1.5 hours respectively. Vomiting in the PACU for the Group I was 4.8 % and 25% at 24 hours post emergence. Group II had a 1.6% incidence of vomiting in the PACU and 14 % at 24 hours. No significant difference was found between these two groups of mostly of female patients. When ondansetron 4 mg IV is administered at induction or emergence from general endotracheal anesthesia, patients experience a similar incidence of PONV in the recovery room and up to 24 hours post emergence.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1997
- Accession Number
- ADA426716
Entities
People
- Bradley West
- Catherine Peuterbaugh
Organizations
- University of Texas Health Science Center at Houston