Modifiers of the Efficacy of Risk-Reducing Salpingo-Oophorectomy for the Prevention of Breast and Ovarian Cancer in Carriers of BRCA1 and BRCA2 Mutations
Abstract
The principal investigator was funded via a Physician-Scientist Training Award to participate in a comprehensive training plan to foster the transition to independent clinical breast cancer researcher. This plan included 1) conduct of a prospective study examining modifiers of the efficacy of risk-reducing salpingo-oophorectomy for the prevention of breast and ovarian cancer in carriers of BRCA mutations; and 2) participation in coursework in research methodology, biostatistics, molecular biology, and ethics. Progress from 5/1/2003 - 4/30/2004 includes: 1) Accrual at a greater than expected rate to the planned research study; 2) Participation in a clinical cancer research methods course with production of a new research proposal for the Gynecologic Oncology Group; 3) Co-authored manuscript examining prostate cancer risk of men with BRCA mutations; and 4) Conducted a pilot study suggesting that women from BRCA-negative hereditary breast cancer families are not at increased risk for ovarian cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA426778
Entities
People
- Noah D. Kauff
Organizations
- Memorial Sloan Kettering Cancer Center