Evaluation of Feasibility for a Case-Control Study of Pituitary-0varian Function in Premenopausal Women With Breast Cancer
Abstract
Postmenopausal women with elevated estrogens are at an increased risk of breast cancer, but an association of estrogens with breast cancer in premenopausal women has not been clearly established. Objective/Hypothesis: We will evaluate the feasibility of a case-control study that uses gonadotropin releasing hormone (GnRH) agonist stimulation tests to compare pituitary-ovarian function in premenopausal women with breast cancer with unaffected controls. Hypotheses to be tested in the full-scale study are: 1) premenopausal women with breast cancer secretes more luteinizing hormone (LH) and follicle stimulating hormone (FSH) in response to GnRH compared to controls; 2) premenopausal women with breast cancer secrete more estradiol and testosterone in response to gonadotropins, and this is related to their higher insulin like growth factor-1 (IGF-1) levels compared to controls; 3) increased estradiol production in premenopausal women with breast cancer is due to increased enzyme activity at a specific step in steroidogenesis. Specific Aims: Specific aims of the feasibility study are: I) determine the feasibility of a full-scale study; 2) gather preliminary data on basal and GnRH stimulated serum levels of LH, FSH, estradiol, and testosterone in women with breast cancer compared to controls. Study Design: A case-control study will be conducted at FCCC.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA427025
Entities
People
- Joanne F. Dorgan
Organizations
- Fox Chase Cancer Center