RIZ Tumor Suppressor and Breast Cancer: The PR Domain

Abstract

Mutations or changes in normal cellular genes are generally linked to human cancer. Multiple gene changes involving at least two types of cancer genes, protooncogenes and tumor suppressor genes, are required for the clonal expansion of a malignant cell. The RIZ gene plays an important role in human cancer and more particularly in breast cancer. RIZ is the founding member of the PR-domain family of zinc finger genes. Two protein products are produced from the RIZ gene which differ by the presence or the absence of the PR domain : RIZ1 and RIZ2. RIZ1 is commonly lost or underexpressed in tumors whereas RIZ2 is always present. RIZl is a tumor suppressor whereas RIZ2 is not. In this project, we are trying to characterize the structural and the functional role of the RIZl-PR and/or related domains using protein crystallography. Our goal is to understand the tumor-suppression mechanism of RIZl and PR-proteins in breast cancer. This will provide us new tools for possible treatment in breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2004
Accession Number
ADA427037

Entities

People

  • Celine Aznar-derunes

Organizations

  • Sanford Burnham Prebys Medical Discovery Institute

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Chemistry
  • Chromosomes
  • Crystal Structure
  • Crystallization
  • Crystallography
  • Crystals
  • Enzyme Inhibitors
  • Ion Exchange
  • Mass Spectroscopy
  • Mutations
  • Neoplasms
  • Protein-Protein Interactions
  • Proteins
  • Suppressors

Readers

  • Criminal Law
  • Molecular Biology and Genetics
  • Molecular and genetic basis of cancer.