Transforming Growth Factor Beta Regulation of Tumor Progression in Metastatic Cancer
Abstract
During the metastatic tumor development, osteoclasts differentiate in the presence of high transforming growth factor beta (TGF-beta) concentrations. We hypothesize that TGF-beta is a survival factor for TGF-beta-induced osteoclasts. We tested our hypothesis by: (l) Determining the effects of TGF-beta on tumor development in bone in vivo and (2) Determining the role of TCF-beta signal transduction in TGF-beta influences on mouse osteoclasts-like cell survival. We have compared mice with cardiac verses direct bone deposition of tumor cells expressing either the constitutively active or the dominant interfering TGF-beta receptors. Cardiac injected mice containing the constitutively active receptor had a significantly lower rate of osteolytic lesion development compared to either the parental cells or the dominant interfering receptor cells. In contrast, there were no differences in parameters of osteolysis between the cell types with direct bone injection. We conclude that the rate of metastasis in impacted by TCF-beta yet the rate of osteolysis is independent of TCF-beta effects on tumor cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2004
- Accession Number
- ADA427069
Entities
People
- Merry Jo Oursler
Organizations
- University of Minnesota