Imaging Primary Prostate Cancer and Bone Metastasis

Abstract

The overall objective of the proposed research is to develop positron emitter labeled bombesin analogs with high affinity for the GRP receptor BB2 for microPET imaging of both androgen dependent and androgen independent prostate cancer xenografted mice. Specific Aims: (1) Design, synthesize, and characterize positrori emitting bombesin analogs, labeled with copper-64 or fluorine-I 8; (2) Conduct in vitro studies of copper-64 and fluorine-18 labeled bombesin analogs to evaluate the effect of modification and radiolabeling on the receptor binding affinity and specificity; (3) Evaluate in vivo efficacy of these novel radiopharmaceuticals in the murine PC-3 and CWR22 human prostate cancer xenograft models.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2004
Accession Number
ADA427071

Entities

People

  • Xiaoyuan Chen

Organizations

  • University of Southern California

Tags

DTIC Thesaurus Topics

  • Androgens
  • Biological Sciences
  • Blood
  • Cancer
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Fluorine
  • Hormones
  • Kinetics
  • Neoplasms
  • Nuclear Medicine
  • Pancreas
  • Prostate
  • Prostate Cancer
  • Radiopharmaceuticals
  • Tissues

Fields of Study

  • Chemistry

Readers

  • Medical Imaging.
  • Oncology (Cancer Research).
  • Prostate Cancer Biology.