Estimation of Tumor Angiogenesis with Contrast Enhanced Subharmonic Ultrasound Imaging
Abstract
New contrast-specific imaging modalities such as harmonic imaging (HI) may improve the accuracy of breast ultrasound. Unfortunately, HI suffers from reduced blood-to-tissue contrast resulting from second harmonic generation and accumulation in tissue. As an alternative we propose using subharmonic imaging (SHI) by transmitting at double the resonance frequency (2f0) and receiving at the subharmonic (f0) . SHI has the potential to detect slow, small volume blood flow associated with tumor neovascularity, making early detection and identification of tumors very likely. Hence, the current project proposes to increase the ability of breast ultrasound to differentiate between benign and malignant lesions by combining injection of an ultrasound contrast agent with SHI. To date, in vivo experiments comparing SHI in canines to perfusion have been completed showing good correlation (r = 0.57; p < 0.0001) with contrast uptake slopes. Otherwise the entire year has been devoted to obtaining the necessary approvals from collaborators as well as regulatory bodies (internal as well as external) in order to commence the human studies. Currently final approvals are expected to be in place by early August, 2004.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2004
- Accession Number
- ADA427074
Entities
People
- Flemming Forsberg
Organizations
- Thomas Jefferson University