Angiogenesis and Stromal Interaction in Breast Cancer
Abstract
Successful tumor growth requires angiogenesis, or the sprouting of new blood vessels from existing ones, to supply tumor cells with essential nutrients and oxygen. In addition, cancer cells must also establish a productive interaction with their neighboring stroma, which produces a matrix environment conducive to tumor growth and may also help shield tumor cells against systemic immune surveillance. A novel angiogenic factor essential for vascular development, Cyr61, has been recently identified as a marker for invasive breast carcinomas. We have found that the receptor for Cyr61 in breast cancer cells is integrin alpha 6 beta 1. Cyr61 also inhibits the proliferation of normal breast epithelial cells and MCF7 carcinoma cells, in part through enhancing apoptotic pathways. A new hypothesis on the role of Cyr61 in breast cancer cell growth is currently being tested.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2004
- Accession Number
- ADA427115
Entities
People
- Lester F. Lau
Organizations
- University of Illinois at Chicago